CRISPR is a new technology that enables scientists to quickly alter the genetic makeup of the entire population of a species. It's so powerful that just one genetically-modified mosquito could eradicate malaria. It's so easy to do that a grad student could (accidentally) enact these global ecological changes from their kitchen. It's also under-regulated. Under science's current culture of secrecy, ensuring that scientists are taking necessary precautions with gene-drive research is next to impossible, says CRISPR innovator Kevin Esvelt. Writing in Nature last summer, Esvelt urged the scientific community to open all experiments to public scrutiny, beginning with the revolutionary and potentially world-changing gene-editing research he helped advance. Also in the podcast, the idea of human cloning captivates and terrifies. Depictions of human clones in science fiction reflect some of our deepest fears about what it means to be human. But not everyone shares those anxieties. For example, the creators of the hit BBC series Orphan Black have developed a show which diverges from the canon of popular culture clone portrayals. Brooke talks with bioethicist Gregory Pence, author of What We Talk About When We Talk About Clone Club, about how Orphan Black reflects and challenges dominant ideas in the debate on human cloning.